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105k-feature whole-genome microarray  (Agilent technologies)


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    Agilent technologies 105k-feature whole-genome microarray
    Identification by oligonucleotide <t>microarray</t> of additional complexity missed by BAC microarray . (A) BAC microarray results showing a single-copy loss of 34 BAC clones from the terminus of 5p, approximately 6.8 Mb in size (chr5: 387,034-7,150,950, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the p-arm probes to the left and q-arm probes to the right. (B) shows oligonucleotide microarray results of the terminal deletion shown in (A) in addition to single-copy gain of 29 probes from 5p, approximately 1.38 Mb in size (chr5: 8,511,592-9,888,817, based on UCSC 2006 hg 18 assembly). Probes are ordered as in the BAC array. Regions shaded in blue represent deletions detected by microarray, whereas duplications are shaded in pink.
    105k Feature Whole Genome Microarray, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/105k-feature+whole-genome+microarray/pmc02909945-242-8-13
    Average 90 stars, based on 1 article reviews
    105k-feature whole-genome microarray - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH"

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    Journal: Molecular Cytogenetics

    doi: 10.1186/1755-8166-3-11

    Identification by oligonucleotide microarray of additional complexity missed by BAC microarray . (A) BAC microarray results showing a single-copy loss of 34 BAC clones from the terminus of 5p, approximately 6.8 Mb in size (chr5: 387,034-7,150,950, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the p-arm probes to the left and q-arm probes to the right. (B) shows oligonucleotide microarray results of the terminal deletion shown in (A) in addition to single-copy gain of 29 probes from 5p, approximately 1.38 Mb in size (chr5: 8,511,592-9,888,817, based on UCSC 2006 hg 18 assembly). Probes are ordered as in the BAC array. Regions shaded in blue represent deletions detected by microarray, whereas duplications are shaded in pink.
    Figure Legend Snippet: Identification by oligonucleotide microarray of additional complexity missed by BAC microarray . (A) BAC microarray results showing a single-copy loss of 34 BAC clones from the terminus of 5p, approximately 6.8 Mb in size (chr5: 387,034-7,150,950, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the p-arm probes to the left and q-arm probes to the right. (B) shows oligonucleotide microarray results of the terminal deletion shown in (A) in addition to single-copy gain of 29 probes from 5p, approximately 1.38 Mb in size (chr5: 8,511,592-9,888,817, based on UCSC 2006 hg 18 assembly). Probes are ordered as in the BAC array. Regions shaded in blue represent deletions detected by microarray, whereas duplications are shaded in pink.

    Techniques Used: Microarray, Clone Assay

    Oligonucleotide microarray analysis of a mosaic 16q12.1 deletion (shaded blue region) . The zoomed-in microarray plot shows a single-copy loss of 289 probes from 16q12.1, approximately 2.77 Mb in size (chr16: 46,837,260-49,605,054, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 16q11.2 probes to the left and the most distal 16q12.2 probes to the right.
    Figure Legend Snippet: Oligonucleotide microarray analysis of a mosaic 16q12.1 deletion (shaded blue region) . The zoomed-in microarray plot shows a single-copy loss of 289 probes from 16q12.1, approximately 2.77 Mb in size (chr16: 46,837,260-49,605,054, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 16q11.2 probes to the left and the most distal 16q12.2 probes to the right.

    Techniques Used: Microarray

    Oligonucleotide microarray analysis of artificially derived mosaic trisomy 21 samples . (A) 10% trisomy 21 showing a very subtle copy-number gain for all clones on chromosome 21. The profile was generated using DNA extracted from a mixture of blood which contained 10% WBCs from a trisomy 21 subject and 90% WBCs from a normal male individual. (B) 15% trisomy 21, generated as in (A), showing a very subtle copy-number gain for all clones on chromosome 21. (C) 20% trisomy 21, generated as in (A) showing a subtle copy-number gain for all clones on chromosome 21. (D) 30% trisomy 21, generated as in (A), showing a clear copy-number gain for all clones on chromosome 21. The inset images to the right of each array plot show the average log 2 ratio of all probes mapping to chromosome 21, with the horizontal dotted line representing a log 2 ratio of zero and the vertical dotted line representing the centromere. A pink bar plotted above the horizontal line represents a copy-number gain of all probes on chromosome 21. To the left of each inset image is the average log 2 ratio at the specified proportion of trisomic cells.
    Figure Legend Snippet: Oligonucleotide microarray analysis of artificially derived mosaic trisomy 21 samples . (A) 10% trisomy 21 showing a very subtle copy-number gain for all clones on chromosome 21. The profile was generated using DNA extracted from a mixture of blood which contained 10% WBCs from a trisomy 21 subject and 90% WBCs from a normal male individual. (B) 15% trisomy 21, generated as in (A), showing a very subtle copy-number gain for all clones on chromosome 21. (C) 20% trisomy 21, generated as in (A) showing a subtle copy-number gain for all clones on chromosome 21. (D) 30% trisomy 21, generated as in (A), showing a clear copy-number gain for all clones on chromosome 21. The inset images to the right of each array plot show the average log 2 ratio of all probes mapping to chromosome 21, with the horizontal dotted line representing a log 2 ratio of zero and the vertical dotted line representing the centromere. A pink bar plotted above the horizontal line represents a copy-number gain of all probes on chromosome 21. To the left of each inset image is the average log 2 ratio at the specified proportion of trisomic cells.

    Techniques Used: Microarray, Derivative Assay, Clone Assay, Generated

    Oligonucleotide microarray characterization of an interstitial deletion at 17p13.3 . The zoomed-in microarray plot shows a single-copy loss of six probes from the short arm of chromosome 17 at 17p13.3, approximately 44.0 kb in size (chr17: 2,415,074-2,459,051, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most distal 17p13.3 probes to the left and the most proximal 17p13.3 probes to the right. Below is a schematic of the deletion region. The deletion disrupts the PAFAH1B1/LIS1 gene.
    Figure Legend Snippet: Oligonucleotide microarray characterization of an interstitial deletion at 17p13.3 . The zoomed-in microarray plot shows a single-copy loss of six probes from the short arm of chromosome 17 at 17p13.3, approximately 44.0 kb in size (chr17: 2,415,074-2,459,051, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most distal 17p13.3 probes to the left and the most proximal 17p13.3 probes to the right. Below is a schematic of the deletion region. The deletion disrupts the PAFAH1B1/LIS1 gene.

    Techniques Used: Microarray

    Oligonucleotide microarray characterization of an interstitial deletion at 6q14.1 . The zoomed-in microarray plot shows a single-copy loss of 43 oligonucleotide probes from the long arm of chromosome 6 at 6q14.1, approximately 2.9 Mb in size (chr6: 79,838,518-82,730,466, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 6q14.1 probes to the left and the most distal 6q14.1 probes to the right. Below is a schematic of the deletion region. Blue and gray boxes represent genes in the deletion region.
    Figure Legend Snippet: Oligonucleotide microarray characterization of an interstitial deletion at 6q14.1 . The zoomed-in microarray plot shows a single-copy loss of 43 oligonucleotide probes from the long arm of chromosome 6 at 6q14.1, approximately 2.9 Mb in size (chr6: 79,838,518-82,730,466, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 6q14.1 probes to the left and the most distal 6q14.1 probes to the right. Below is a schematic of the deletion region. Blue and gray boxes represent genes in the deletion region.

    Techniques Used: Microarray

    BAC microarray characterization of a 9q33.1 deletion . The zoomed-in microarray plot shows a single-copy loss of three BAC clones from the long arm of chromosome 9 at 9q33.1, approximately 262 kb in size (chr9: 119,452,279-119,714,054 based on UCSC 2006 hg 18 assembly). The nearest distal clone on chromosome 9 that is not deleted is RP11-977E8 and is approximately 4.0 Mb away from the deleted region. The nearest proximal clone on chromosome 9 that is not deleted is RP11-999I23 and is approximately 4.4 Mb away from the deleted region. Probes are ordered on the x axis according to physical mapping positions, with proximal 9q32 clones to the left and distal 9q33.2 clones to the right. Below is a schematic of the deletion region. Vertical blue lines represent the minimum size of this alteration, which encompasses one gene, TLR4 .
    Figure Legend Snippet: BAC microarray characterization of a 9q33.1 deletion . The zoomed-in microarray plot shows a single-copy loss of three BAC clones from the long arm of chromosome 9 at 9q33.1, approximately 262 kb in size (chr9: 119,452,279-119,714,054 based on UCSC 2006 hg 18 assembly). The nearest distal clone on chromosome 9 that is not deleted is RP11-977E8 and is approximately 4.0 Mb away from the deleted region. The nearest proximal clone on chromosome 9 that is not deleted is RP11-999I23 and is approximately 4.4 Mb away from the deleted region. Probes are ordered on the x axis according to physical mapping positions, with proximal 9q32 clones to the left and distal 9q33.2 clones to the right. Below is a schematic of the deletion region. Vertical blue lines represent the minimum size of this alteration, which encompasses one gene, TLR4 .

    Techniques Used: Microarray, Clone Assay

    Oligonucleotide microarray characterization of an interstitial deletion at 4q25 . The zoomed-in microarray plots shows a single-copy loss of 15 oligonucleotide probes from the long arm of chromosome 4 at 4q25, approximately 159.6 kb in size (chr4: 108,834,399-108,994,048, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with proximal 4q25 clones to the left and distal 4q25 clones to the right. Below is a schematic of the deletion region. The deletion disrupts the PAPSS1 and SGMS2 genes, represented by blue boxes.
    Figure Legend Snippet: Oligonucleotide microarray characterization of an interstitial deletion at 4q25 . The zoomed-in microarray plots shows a single-copy loss of 15 oligonucleotide probes from the long arm of chromosome 4 at 4q25, approximately 159.6 kb in size (chr4: 108,834,399-108,994,048, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with proximal 4q25 clones to the left and distal 4q25 clones to the right. Below is a schematic of the deletion region. The deletion disrupts the PAPSS1 and SGMS2 genes, represented by blue boxes.

    Techniques Used: Microarray, Clone Assay

    Related Articles

    Microarray:

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Clone Assay:

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Derivative Assay:

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Generated:

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.



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    105k-feature whole-genome microarray  (Agilent technologies)
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    Agilent technologies 105k-feature whole-genome microarray
    Identification by oligonucleotide <t>microarray</t> of additional complexity missed by BAC microarray . (A) BAC microarray results showing a single-copy loss of 34 BAC clones from the terminus of 5p, approximately 6.8 Mb in size (chr5: 387,034-7,150,950, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the p-arm probes to the left and q-arm probes to the right. (B) shows oligonucleotide microarray results of the terminal deletion shown in (A) in addition to single-copy gain of 29 probes from 5p, approximately 1.38 Mb in size (chr5: 8,511,592-9,888,817, based on UCSC 2006 hg 18 assembly). Probes are ordered as in the BAC array. Regions shaded in blue represent deletions detected by microarray, whereas duplications are shaded in pink.
    105k Feature Whole Genome Microarray, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/105k-feature+whole-genome+microarray/pmc02909945-242-8-13
    Average 90 stars, based on 1 article reviews
    105k-feature whole-genome microarray - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Identification by oligonucleotide microarray of additional complexity missed by BAC microarray . (A) BAC microarray results showing a single-copy loss of 34 BAC clones from the terminus of 5p, approximately 6.8 Mb in size (chr5: 387,034-7,150,950, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the p-arm probes to the left and q-arm probes to the right. (B) shows oligonucleotide microarray results of the terminal deletion shown in (A) in addition to single-copy gain of 29 probes from 5p, approximately 1.38 Mb in size (chr5: 8,511,592-9,888,817, based on UCSC 2006 hg 18 assembly). Probes are ordered as in the BAC array. Regions shaded in blue represent deletions detected by microarray, whereas duplications are shaded in pink.

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: Identification by oligonucleotide microarray of additional complexity missed by BAC microarray . (A) BAC microarray results showing a single-copy loss of 34 BAC clones from the terminus of 5p, approximately 6.8 Mb in size (chr5: 387,034-7,150,950, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the p-arm probes to the left and q-arm probes to the right. (B) shows oligonucleotide microarray results of the terminal deletion shown in (A) in addition to single-copy gain of 29 probes from 5p, approximately 1.38 Mb in size (chr5: 8,511,592-9,888,817, based on UCSC 2006 hg 18 assembly). Probes are ordered as in the BAC array. Regions shaded in blue represent deletions detected by microarray, whereas duplications are shaded in pink.

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray, Clone Assay

    Oligonucleotide microarray analysis of a mosaic 16q12.1 deletion (shaded blue region) . The zoomed-in microarray plot shows a single-copy loss of 289 probes from 16q12.1, approximately 2.77 Mb in size (chr16: 46,837,260-49,605,054, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 16q11.2 probes to the left and the most distal 16q12.2 probes to the right.

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: Oligonucleotide microarray analysis of a mosaic 16q12.1 deletion (shaded blue region) . The zoomed-in microarray plot shows a single-copy loss of 289 probes from 16q12.1, approximately 2.77 Mb in size (chr16: 46,837,260-49,605,054, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 16q11.2 probes to the left and the most distal 16q12.2 probes to the right.

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray

    Oligonucleotide microarray analysis of artificially derived mosaic trisomy 21 samples . (A) 10% trisomy 21 showing a very subtle copy-number gain for all clones on chromosome 21. The profile was generated using DNA extracted from a mixture of blood which contained 10% WBCs from a trisomy 21 subject and 90% WBCs from a normal male individual. (B) 15% trisomy 21, generated as in (A), showing a very subtle copy-number gain for all clones on chromosome 21. (C) 20% trisomy 21, generated as in (A) showing a subtle copy-number gain for all clones on chromosome 21. (D) 30% trisomy 21, generated as in (A), showing a clear copy-number gain for all clones on chromosome 21. The inset images to the right of each array plot show the average log 2 ratio of all probes mapping to chromosome 21, with the horizontal dotted line representing a log 2 ratio of zero and the vertical dotted line representing the centromere. A pink bar plotted above the horizontal line represents a copy-number gain of all probes on chromosome 21. To the left of each inset image is the average log 2 ratio at the specified proportion of trisomic cells.

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: Oligonucleotide microarray analysis of artificially derived mosaic trisomy 21 samples . (A) 10% trisomy 21 showing a very subtle copy-number gain for all clones on chromosome 21. The profile was generated using DNA extracted from a mixture of blood which contained 10% WBCs from a trisomy 21 subject and 90% WBCs from a normal male individual. (B) 15% trisomy 21, generated as in (A), showing a very subtle copy-number gain for all clones on chromosome 21. (C) 20% trisomy 21, generated as in (A) showing a subtle copy-number gain for all clones on chromosome 21. (D) 30% trisomy 21, generated as in (A), showing a clear copy-number gain for all clones on chromosome 21. The inset images to the right of each array plot show the average log 2 ratio of all probes mapping to chromosome 21, with the horizontal dotted line representing a log 2 ratio of zero and the vertical dotted line representing the centromere. A pink bar plotted above the horizontal line represents a copy-number gain of all probes on chromosome 21. To the left of each inset image is the average log 2 ratio at the specified proportion of trisomic cells.

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray, Derivative Assay, Clone Assay, Generated

    Oligonucleotide microarray characterization of an interstitial deletion at 17p13.3 . The zoomed-in microarray plot shows a single-copy loss of six probes from the short arm of chromosome 17 at 17p13.3, approximately 44.0 kb in size (chr17: 2,415,074-2,459,051, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most distal 17p13.3 probes to the left and the most proximal 17p13.3 probes to the right. Below is a schematic of the deletion region. The deletion disrupts the PAFAH1B1/LIS1 gene.

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: Oligonucleotide microarray characterization of an interstitial deletion at 17p13.3 . The zoomed-in microarray plot shows a single-copy loss of six probes from the short arm of chromosome 17 at 17p13.3, approximately 44.0 kb in size (chr17: 2,415,074-2,459,051, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most distal 17p13.3 probes to the left and the most proximal 17p13.3 probes to the right. Below is a schematic of the deletion region. The deletion disrupts the PAFAH1B1/LIS1 gene.

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray

    Oligonucleotide microarray characterization of an interstitial deletion at 6q14.1 . The zoomed-in microarray plot shows a single-copy loss of 43 oligonucleotide probes from the long arm of chromosome 6 at 6q14.1, approximately 2.9 Mb in size (chr6: 79,838,518-82,730,466, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 6q14.1 probes to the left and the most distal 6q14.1 probes to the right. Below is a schematic of the deletion region. Blue and gray boxes represent genes in the deletion region.

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: Oligonucleotide microarray characterization of an interstitial deletion at 6q14.1 . The zoomed-in microarray plot shows a single-copy loss of 43 oligonucleotide probes from the long arm of chromosome 6 at 6q14.1, approximately 2.9 Mb in size (chr6: 79,838,518-82,730,466, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with the most proximal 6q14.1 probes to the left and the most distal 6q14.1 probes to the right. Below is a schematic of the deletion region. Blue and gray boxes represent genes in the deletion region.

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray

    BAC microarray characterization of a 9q33.1 deletion . The zoomed-in microarray plot shows a single-copy loss of three BAC clones from the long arm of chromosome 9 at 9q33.1, approximately 262 kb in size (chr9: 119,452,279-119,714,054 based on UCSC 2006 hg 18 assembly). The nearest distal clone on chromosome 9 that is not deleted is RP11-977E8 and is approximately 4.0 Mb away from the deleted region. The nearest proximal clone on chromosome 9 that is not deleted is RP11-999I23 and is approximately 4.4 Mb away from the deleted region. Probes are ordered on the x axis according to physical mapping positions, with proximal 9q32 clones to the left and distal 9q33.2 clones to the right. Below is a schematic of the deletion region. Vertical blue lines represent the minimum size of this alteration, which encompasses one gene, TLR4 .

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: BAC microarray characterization of a 9q33.1 deletion . The zoomed-in microarray plot shows a single-copy loss of three BAC clones from the long arm of chromosome 9 at 9q33.1, approximately 262 kb in size (chr9: 119,452,279-119,714,054 based on UCSC 2006 hg 18 assembly). The nearest distal clone on chromosome 9 that is not deleted is RP11-977E8 and is approximately 4.0 Mb away from the deleted region. The nearest proximal clone on chromosome 9 that is not deleted is RP11-999I23 and is approximately 4.4 Mb away from the deleted region. Probes are ordered on the x axis according to physical mapping positions, with proximal 9q32 clones to the left and distal 9q33.2 clones to the right. Below is a schematic of the deletion region. Vertical blue lines represent the minimum size of this alteration, which encompasses one gene, TLR4 .

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray, Clone Assay

    Oligonucleotide microarray characterization of an interstitial deletion at 4q25 . The zoomed-in microarray plots shows a single-copy loss of 15 oligonucleotide probes from the long arm of chromosome 4 at 4q25, approximately 159.6 kb in size (chr4: 108,834,399-108,994,048, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with proximal 4q25 clones to the left and distal 4q25 clones to the right. Below is a schematic of the deletion region. The deletion disrupts the PAPSS1 and SGMS2 genes, represented by blue boxes.

    Journal: Molecular Cytogenetics

    Article Title: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

    doi: 10.1186/1755-8166-3-11

    Figure Lengend Snippet: Oligonucleotide microarray characterization of an interstitial deletion at 4q25 . The zoomed-in microarray plots shows a single-copy loss of 15 oligonucleotide probes from the long arm of chromosome 4 at 4q25, approximately 159.6 kb in size (chr4: 108,834,399-108,994,048, based on UCSC 2006 hg 18 assembly). Probes are ordered on the x axis according to physical mapping positions, with proximal 4q25 clones to the left and distal 4q25 clones to the right. Below is a schematic of the deletion region. The deletion disrupts the PAPSS1 and SGMS2 genes, represented by blue boxes.

    Article Snippet: Oligonucleotide-based microarray analysis was performed using a custom-designed, 105K-feature whole-genome microarray manufactured by Agilent Technologies (Santa Clara, CA) with one probe every 10 kb in regions of interest--microdeletion/microduplication syndromes, the pericentromeric regions, subtelomeres and genes involved in important developmental pathways--for an average of 50 oligos per clinical locus.

    Techniques: Microarray, Clone Assay